(Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding,National Engineering Research Center for Breeding Swine Industry,College of Animal Science,South China Agricultural University,Guangzhou 510642,China)
[1]HAMMER R E,PURSEL V G,REXROAD C E J R,et al.Production of transgenic rabbits,sheep and pigs by microinjection[J].Nature,1985,315(6021):680-683.
[2]GOLOVAN S P,MEIDINGER R G,AJAKAIYE A,et al.Pigs expressing salivary phytase produce low-phosphorus manure[J].Nat Biotechnol,2001,19(8):741-745.
[3]GARRELS W,MÁTÉS L,HOLLER S,et al.Germline transgenic pigs by sleeping beauty transposition in porcine zygotes and targeted integration in the pig genome[J].PLoS One,2011,6(8):e23573.
[4]LI Z,ZENG F,MENG F,et al.Generation of transgenic pigs by cytoplasmic injection of piggyBac transposase-based pmGENIE-3 plasmids[J].Biol Reprod,2014,90(5):93.
[5]WILMUT I,SCHNIEKE A E,MCWHIR J,et al.Viable offspring derived from fetal and adult mammalian cells[J].Nature,1997,385(6619):810-813.
[6]WHITWORTH K M,PRATHER R S.Somatic cell nuclear transfer efficiency:how can it be improved through nuclear remodeling and reprogramming?[J].Mol Reprod Dev,2010,77(12):1001-1015.
[7]ZHAO J,WHYTE J,PRATHER R S.Effect of epigenetic regulation during swine embryogenesis and on cloning by nuclear transfer[J].Cell Tissue Res,2010,341(1):13-21.
[8]YANG X,SMITH S L,TIAN X C,et al.Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning[J].Nat Genet,2007,39(3):295-302.
[9]WEI H,QING Y,PAN W,et al.Comparison of the efficiency of Banna miniature inbred pig somatic cell nuclear transfer among different donor cells[J].PLoS One,2013,8(2):e57728.
[10]ZHANG D F,LIU D,TANG L L,et al.Effects of different donor cells on the development of nuclear-transferred porcine embryos[J].Hereditas,2007,29(2):211-217.
[11]张德福,刘东,汤琳琳,等.体细胞的组织来源及培养代数对猪核移植重构胚发育的影响[J].分子细胞生物学报,2006,39(2):145-151.(in Chinese)
ZHANG D F,LIU D,TANG L L,et al.Effects of different donor cells and passages on the development of nuclear transfer porcine embryos[J].Journal of Molecular Cell Biology,2006,39(2):145-151.
[12]DENG W,YANG D,ZHAO B,et al.Use of the 2A peptide for generation of multi-transgenic pigs through a single round of nuclear transfer[J].PLoS One,2011,6(5):e19986.
[13]UMEYAMA K,SAITO H,KUROME M,et al.Characterization of the ICSI-mediated gene transfer method in the production of transgenic pigs[J].Mol Reprod Dev,2012,79(3):218-228.
[14]WU Z F,XU Z Q,ZOU X,et al.Pig transgenesis by piggyBac transposition in combination with somatic cell nuclear transfer[J].Transgenic Res,2013,22(6):1107-1118.
[15]URNOV F D,MILLER J C,LEE Y L,et al.Highly efficient endogenous human gene correction using designed zinc-finger nucleases[J].Nature,2005,435(7042):646-651.
[16]CHRISTIAN M,CERMAK T,DOYLE E L,et al.Targeting DNA double-strand breaks with TAL effector nucleases[J].Genetics,2010,186(2):757-761.
[17]CONG L,RAN F A,COX D,et al.Multiplex genome engineering using CRISPR/Cas systems[J].Science,2013,339(6121):819-823.
[18]MALI P,YANG L,ESVELT K M,et al.RNA-guided human genome engineering via Cas9[J].Science,2013,339(6121):823-826.
[19]ZHOU X,XIN J,FAN N,et al.Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer[J].Cell Mol Life Sci,2015,72(6):1175-1184.
[20]BAO L,CHEN H,JONG U,et al.Generation of GGTA1 biallelic knockout pigs via zinc-finger nucleases and somatic cell nuclear transfer[J].Sci China Life Sci,2014,57(2):263-268.
[21]REYES L M,ESTRADA J L,WANG Z Y,et al.Creating class I MHC-null pigs using guide RNA and the Cas9 endonuclease[J].J Immunol,2014,193(11):5751-5757.
[22]XIN J,YANG H,FAN N,et al.Highly efficient generation of GGTA1 biallelic knockout inbred mini-pigs with TALENs[J].PLoS ONE,2013,8(12):e84250.
[23]SAEKI K,MATSUMOTO K,KINOSHITA M,et al.Functional expression of a Delta12 fatty acid desaturase gene from spinach in transgenic pigs[J].Proc Natl Acad Sci U S A,2004,101(17):6361-6366.
[24]LAI L,KANG J X,LI R,et al.Generation of cloned transgenic pigs rich in omega-3 fatty acids[J].Nat Biotechnol,2006,24(4):435-436.
[25]潘登科,张莉,周艳荣,等.体细胞核移植生产转ω-3脂肪酸去饱和酶基因sFat-1克隆猪[J].中国科学(C辑:生命科学),2009,39(3):295-302.
PANG D K,ZHANG L,ZHOU Y R,et al.Production of ω-3 fatty acid desaturase gene(sfat-1) transgenic pigs by somatic cell nuclear transfer[J].Science in China (Series C:Life Sciences),2009,39(3):295-302.(in Chinese)
[26]MILLER K F,BOLT D J,PURSEL V G,et al.Expression of human or bovine growth hormone gene with a mouse metallothionein-1 promoter in transgenic swine alters the secretion of porcine growth hormone and insulin-like growth factor-I[J].J Endocrinol,1989,120(3):481-488.
[27]PURSEL V G,PINKERT C A,MILLER K F,et al.Genetic engineering of livestock[J].Science,1989,244(4910):1281-1288.
[28]PURSEL V G,BOLT D J,MILLER K F,et al.Expression and performance in transgenic pigs[J].J Reprod Fertil Suppl,1990,40:235-245.
[29]PURSEL V G,MITCHELL A D,BEE G,et al.Growth and tissue accretion rates of swine expressing an insulin-like growth factor I transgene[J].Anim Biotechnol,2004,15(1):33-45.
[30]АНДРЕЕВА Л Е.猪胚胎的人生长激素释放因子基因微注射[J].国外畜牧科技,1992,19(4):5-6.
АНДРЕЕВА Л Е.Microinjection of human growth hormone into swine embryos[J].Animal Science Abroad,1992,19(4):5-6.(in Chinese)
[31]魏庆信,樊俊华,陈东宝,等.湖北白猪导入OMT/PGH基因的整合、表达和遗传[J].华中农业大学学报,1993,12(6):606-611.
WEI Q X,FAN J H,CHEN D B,et al.Integration,expression and heredity of OMT/PGH gene transferred into Hubei white pigs[J].Journal of Huazhong Agricultural University,1993,12(6):606-611.(in Chinese)
[32]陈清轩,曹颉,宋德秀,等.猪生长激素基因表达质粒的构建及其转基因动物研究[J].生物化学杂志,1997,13(5):540-545.
CHEN Q X,CAO J,SONG D X,et al.The construction of procine growth hormone gene expressive plasmid and the studies of transgenic animals[J].Chinese Biochemical Journal,1997,13(5):540-545.(in Chinese)
[33]王铁东.抗猪瘟病毒转基因猪的构建及初步研究[D].长春:吉林大学,2009.
WANG T D.Preliminary studies on the production of transgenic pigs which can resist classical swine fever virus infection[D].Changchun:Jilin University,2009.(in Chinese)
[34]TONG J,WEI H,LIU X,et al.Production of recombinant human lysozyme in the milk of transgenic pigs[J].Transgenic Res,2011,20(2):417-419.
[35]LU D,LI Q,WU Z,et al.High-level recombinant human lysozyme expressed in milk of transgenic pigs can inhibit the growth of Escherichia coli in the duodenum and influence intestinal morphology of sucking pigs[J].PLoS One,2014,9(2):e89130.
[36]YAN Q,YANG H,YANG D,et al.Production of transgenic pigs over-expressing the antiviral gene Mx1[J].Cell Regen (Lond),2014,3(1):11.
[37]LO D,PURSEL V,LINTON P J,et al.Expression of mouse IgA by transgenic mice,pigs and sheep[J].Eur J Immunol,1991,21(4):1001-1006.
[38]MÜLLER M,BRENIG B,WINNACKER E L,et al.Transgenic pigs carrying cDNA copies encoding the murine Mx1 protein which confers resistance to influenza virus infection[J].Gene,1992,121(2):263-270.
[39]LU D,LIU S,SHANG S,et al.Production of transgenic-cloned pigs expressing large quantities of recombinant human lysozyme in milk[J].PLoS One,2015,10(5):e123551.
[40]CUI D,LI J,ZHANG L,et al.Generation of bi-transgenic pigs overexpressing human lactoferrin and lysozyme in milk[J].Transgenic Res,2015,24(2):365-373.
[41]LI L,LI Q,BAO Y,et al.RNAi-based inhibition of porcine reproductive and respiratory syndrome virus replication in transgenic pigs[J].J Biotechnol,2014,171:17-24.
[42]GOLOVAN S P,MEIDINGER R G,AJAKAIYE A,et al.Pigs expressing salivary phytase produce low-phosphorus manure[J].Nat Biotechnol,2001,19(8):741-745.
[43]FORSBERG C W,MEIDINGER R G,LIU M,et al.Integration,stability and expression of the E.coli phytase transgene in the Cassie line of Yorkshire EnviropigTM[J].Transgenic Res,2013,22(2):379-389.
[44]张献伟.共表达葡聚糖酶-木聚糖酶-植酸酶转基因猪的研究[D].广州:华南农业大学,2014.
ZHANG X W.Study on transgenic pigs co-expressing β-glucanase-xylanase-phytase[D].Guangzhou:South China Agricultural University,2014.(in Chinese)
[45]LIN Y S,YANG C C,HSU C C,et al.Establishment of a novel,eco-friendly transgenic pig model using porcine pancreatic amylase promoter-driven fungal cellulase transgenes[J].Transgenic Res,2015,24(1):61-71.